Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma

Abstract Some patients with severe asthma experience exacerbations despite receiving multiple therapy. The risk of exacerbation and heterogeneous response to treatment may be associated specific inflammatory molecules that are responsive or resistant corticosteroids. We aimed identify the independent factors predictive for future in asthma. In this multi-center prospective observational study, 132 were enrolled divided into (n = 52) non-exacerbation 80) groups on basis rate after a 1-year follow-up period. found previous history severe-to-serious exacerbation, baseline blood eosinophil counts (? 291cells/?L), serum tryptase (? 1448 pg/mL) thrymic stromal lymphopoietin (TSLP) levels 25 independently predicted development adjusted odds ratios (AOR) 3.27, 6.04, 2.53 8.67, respectively. Notably, high low likely have more than those (AOR 16.9). TSLP potentially played pathogenic role across different phenotypes. implicated steroid resistance responsiveness process. High predict probability exacerbation.